Melanoma is a potentially fatal form of skin cancer.

Early and accurate diagnosis of melanoma is critical for long-term survival.1

Myriad myPath™ Melanoma

What is myPath® Melanoma?

Myriad Genetic Laboratories has developed myPath® Melanoma, a clinically validated test to be used as an adjunct to histopathology when the distinction between a benign nevus and a malignant melanoma cannot be made confidently by histopathology alone.

The test measures the expression of 23 genes by qRT-PCR methodology and distinguishes melanoma from nevi with a sensitivity of 90-94% and a specificity of 91-96%.7,29,30





How the myPath Melanoma Test Works


The myPath Melanoma test measures 23 genes for which expression patterns differ between malignant melanoma and benign nevi. These genes are involved in cell differentiation, cell signaling, and immune response signaling.

An algorithm is applied that combines the measurements of gene expression, assigns a weight to each gene component, and establishes a threshold value. The result is a single numerical score that classifies a melanocytic lesion as ‘likely benign,’ ‘likely malignant,’ or ‘indeterminate.’