Publications & Posters

TYPE TITLE AUTHORS REFERENCE
Clinical Validation 1 Clinical validation of a gene expression signature that differentiates benign nevi from malignant melanoma Loren E. Clarke, M.B. Warf, Darl D. Flake II, Anne-Renee Hartman, Steven Tahan, Christopher R. Shea, Pedram Gerami, Jane Messina, Scott R. Florell, Richard J. Wenstrup, Kristen Rushton, Kirstin M. Roundy, Colleen Rock, Benjamin Roa, Kathryn A. Kolquist, Alexander Gutin, Steven Billings, Sancy Leachman J Cutan Pathol. 2015 Apr;42(4):244-52. doi: 10.1111/cup.12475. Epub 2015 Apr 13
Clinical Validation 2 An independent validation of a gene expression signature to differentiate malignant melanoma from benign melanocytic nevi Loren E. Clarke, Darl D. Flake II, Klaus Busam, Clay Cockerell, Klaus Helm, Jennifer McNiff, Jon Reed, Jaime Tschen, Jinah Kim, Raymond Barnhill, Rosalie Elenitsas, Victor G. Prieto, Jonathan Nelson, Hillary Kimbrell, Kathryn A. Kolquist, Krystal L. Brown, M. Bryan Warf, Benjamin B. Roa, Richard J. Wenstrup Cancer. 2016 Oct 21. doi: 10.1002/cncr.30385.
Clinical Validation 3 Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes Ko J, Matharoo-Ball B, Billings SD, Thomson BJ, Tang JY, Sarin KY, Cai E, Kim J, Rock C, Kimbrell H, Flake DD, Warf MB, Nelson J, Davis T, Miller C, Rushton K, Hartman AR, Wenstrup RJ, Clarke LE. Cancer Epidemiol Biomarkers Prev. 2017 Apr 4. pii: cebp.0958.2016. doi: 10.1158/1055-9965.EPI-16-0958.
Clinical Validation 4 Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma Loren E. Clarke, Jason D. Pimentel, Hillary Zalaznick, Lu Wang, Klaus J. Busam Hum Pathol. 2017 Dec;70:113-120. doi: 10.1016/j.humpath.2017.10.005. Epub 2017 Oct 24.
Clinical Validation 5 Correlation of melanoma gene expression score with clinical outcomes on a series of melanocytic lesions Jennifer S. Ko, Loren E. Clarke, Eugen C. Minca, Krystal Brown, Darl D. Flake, Steven Billings Hum Pathol. 2019 Apr;86:213-221. doi: 10.1016/j.humpath.2018.12.001. Epub 2018 Dec 17.
Clinical Utility 1 The influence of a gene expression signature on the diagnosis and recommended treatment of melanocytic tumors by dermatopathologists Clay J Cockerell, Jaime Tschen, Brent Evans, Emily Bess, Jason Kidd, Kathryn A Kolquist, Colleen Rock, Loren E Clarke Medicine (Baltimore). 2016 Oct;95(40):e4887.
Clinical Utility 2 The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions Clay Cockerell, Jaime Tschen, Steven D Billings, Brent Evans, Krystal Brown, Colleen Rock & Loren E Clarke Per Med. 2017;14(2):123-130.
Analytical Validation Analytical validation of a melanoma diagnostic gene signature using formalin-fixed paraffin-embedded melanocytic lesions M. Bryan Warf, Darl D. Flake II, Doug Adams, Alexander Gutin, Kathryn A. Kolquist, Richard J. Wenstrup, Benjamin B. Roa Biomark Med. 2015;9(5):407-16. doi: 10.2217/bmm.15.11. Epub 2015 Mar 27.
TITLE AUTHORS CONFERENCE
Gene Expression Signature as an Ancillary Method in the Diagnosis of Desmoplastic Melanoma Loren E. Clarke, MD , Jason D. Pimental , Hillary Z. Kimbrell , Klaus J. Busam MD ASDP, Oct 2016, Chicago IL
Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes Jennifer Ko, Balwir Matharoo-Ball, Steven Billings, Brian Thomson, Jean Tang, Kavita Sarin, Emily Cai, Jinah Kim, Colleen Rock, Hillary Kimbrell, Darl Flake, Bryan Warf, Jonathan Nelson, Thaylon Davis, Catherine Miller, Kristen Rushton, Anne-Renee Hartman, Richard Wenstrup, Loren Clarke ASDP, Oct 2016, Chicago IL
An Independent Validation of a Gene Expression Signature to Differentiate Malignant Melanoma from Benign Melanocytic Nevi H. Kimbrell, MD; L. E. Clarke, MD; D. D. Flake II, MS; K. Busam, MD; C. Cockerell, MD; K. Helm, MD; J. McNiff, MD; J. Reed, MD; J. Tschen, MD; J. Kim, MD; R. Barnhill, MD; R. Elenitsas, MD; V. G. Prieto, MD ; J. Nelson, BS; K. A. Kolquist, MD; K. L. Brown, PhD; M. B. Warf, PhD; B. B. Roa, PhD; R. J. Wenstrup, MD USCAP 2016, Mar 2016, Seattle WA
A Retrospective Study of the Influence of a Gene Expression Signature on the Treatment of the Melanocytic Tumors by Dermatologists Clay J. Cockerell, Jaime Tschen, Steven D. Billings, Colleen Rock, Brent Evans, Loren E. Clarke AAD, Mar 2015, San Francisco CA
A Retrospective Study of the Influence of a Gene Expression Signature on the Treatment of the Melanocytic Tumors Colleen Rock, PharmD, PhD; Clay Cockerell, MD; Jaime Tschen, MD; Steven Billings, MD; Brent Evans, MS; John Kidd, MS; Krystal Brown, PhD; Loren E. Clarke, MD ASDP, Oct 2015, San Francisco CA
A Clinically Validated Gene Expression Score Impacts Diagnosis and Management Recommendations of Melanocytic Lesions by Dermatopathologists Loren E Clarke, Emily Bess, Brent Evans, John Kidd, Kathryn A Kolquist, Colleen Rock NCCN, March 2015
A Clinically Validated Gene Expression Score Impacts Diagnosis and Management Recommendations of Melanocytic Lesions by Dermatopathologists Loren E Clarke, Emily Bess, Kathryn Kolquist, Brent Evans, Kelsey Moyes, Colleen Rock CAP 2014, September 2014, Chicago IL- Poster Presentation
The Influence Of A Gene Expression Signature On The Diagnosis And Recommended Treatment Of Melanocytic Tumors By Dermatopathologists Loren E Clarke, Emily Bess, Kelsey Moyes, Brent Evans, Kathryn A Kolquist, Colleen Rock ASCO 2014, May 2014, Chicago, IL- Poster Presentation
Development And Validation Of A Gene Expression Signature To Distinguish Malignant Melanoma From Benign Nevi Colleen Rock, Loren E Clarke, M. Bryan Warf, Darl D Flake II, Anne-Renee Hartman, Steven Tahan, Christopher R. Shea, Pedram Gerami, Jane Messina, Richard J. Wenstrup, Kristen Rushton, Kirstin M. Roundy, Benjamin Roa, Kathryn A. Kolquist, Alexander Gutin, Steven D. Billings, Sancy Ann Leachman. ASCO 2014, May 2014, Chicago, IL- Poster Presentation
Development of a Gene Expression Signature to Differentiate Malignant Melanoma From Benign Melanocytic Nevi Loren E. Clarke, Carola Berking, Steven Tahan, Christopher R. Shea, Darl D. Flake II, Alexander Gutin, Kathryn A. Kolquist, Anne-Renee Hartman, Benjamin Roa, and M. Bryan Warf. Society for Melanoma Research International Congress, November 17-19, 2013, Philadelphia, PA- Poster Presentation
The Clinical Impact of a Gene Expression Signature That Differentiates Benign Nevi From Malignant Melanoma Colleen Rock, Steven D. Billings, Klaus J. Busam, David E. Elder, Pedram Gerami, Melissa Gill, Jane L. Messina, Steven R. Tahan, Kelsey Moyes, M. Bryan Warf, Sancy A. Leachman, Loren E. Clarke United States and Canada Academy of Pathology, March 5, 2014, San Diego, CA. Poster Presentation

Publications

Clinical Validation 1

Clinical validation of a gene expression signature that differentiates benign nevi from malignant melanoma

Authors: Loren E. Clarke, M.B. Warf, Darl D. Flake II, Anne-Renee Hartman, Steven Tahan, Christopher R. Shea, Pedram Gerami, Jane Messina, Scott R. Florell, Richard J. Wenstrup, Kristen Rushton, Kirstin M. Roundy, Colleen Rock, Benjamin Roa, Kathryn A. Kolquist, Alexander Gutin, Steven Billings, Sancy Leachman

Reference: J Cutan Pathol. 2015 Apr;42(4):244-52. doi: 10.1111/cup.12475. Epub 2015 Apr 13


Clinical Validation 2

An independent validation of a gene expression signature to differentiate malignant melanoma from benign melanocytic nevi

Authors: Loren E. Clarke, Darl D. Flake II, Klaus Busam, Clay Cockerell, Klaus Helm, Jennifer McNiff, Jon Reed, Jaime Tschen, Jinah Kim, Raymond Barnhill, Rosalie Elenitsas, Victor G. Prieto, Jonathan Nelson, Hillary Kimbrell, Kathryn A. Kolquist, Krystal L. Brown, M. Bryan Warf, Benjamin B. Roa, Richard J. Wenstrup

Reference: Cancer. 2016 Oct 21. doi: 10.1002/cncr.30385.


Clinical Validation 3

Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Authors: Ko J, Matharoo-Ball B, Billings SD, Thomson BJ, Tang JY, Sarin KY, Cai E, Kim J, Rock C, Kimbrell H, Flake DD, Warf MB, Nelson J, Davis T, Miller C, Rushton K, Hartman AR, Wenstrup RJ, Clarke LE.

Reference: Cancer Epidemiol Biomarkers Prev. 2017 Apr 4. pii: cebp.0958.2016. doi: 10.1158/1055-9965.EPI-16-0958.


Clinical Validation 4

Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma

Authors: Loren E. Clarke, Jason D. Pimentel, Hillary Zalaznick, Lu Wang, Klaus J. Busam

Reference: Hum Pathol. 2017 Dec;70:113-120. doi: 10.1016/j.humpath.2017.10.005. Epub 2017 Oct 24.


Clinical Validation 5

Correlation of melanoma gene expression score with clinical outcomes on a series of melanocytic lesions

Authors: Jennifer S. Ko, Loren E. Clarke, Eugen C. Minca, Krystal Brown, Darl D. Flake, Steven Billings

Reference: Hum Pathol. 2019 Apr;86:213-221. doi: 10.1016/j.humpath.2018.12.001. Epub 2018 Dec 17.


Clinical Utility 1

The influence of a gene expression signature on the diagnosis and recommended treatment of melanocytic tumors by dermatopathologists

Authors: Clay J Cockerell, Jaime Tschen, Brent Evans, Emily Bess, Jason Kidd, Kathryn A Kolquist, Colleen Rock, Loren E Clarke

Reference: Medicine (Baltimore). 2016 Oct;95(40):e4887.


Clinical Utility 2

The influence of a gene-expression signature on the treatment of diagnostically challenging melanocytic lesions

Authors: Clay Cockerell, Jaime Tschen, Steven D Billings, Brent Evans, Krystal Brown, Colleen Rock & Loren E Clarke

Reference: Per Med. 2017;14(2):123-130.


Analytical Validation

Analytical validation of a melanoma diagnostic gene signature using formalin-fixed paraffin-embedded melanocytic lesions

Authors: M. Bryan Warf, Darl D. Flake II, Doug Adams, Alexander Gutin, Kathryn A. Kolquist, Richard J. Wenstrup, Benjamin B. Roa

Reference: Biomark Med. 2015;9(5):407-16. doi: 10.2217/bmm.15.11. Epub 2015 Mar 27.

Posters

Poster 1

Gene Expression Signature as an Ancillary Method in the Diagnosis of Desmoplastic Melanoma

Authors: Loren E. Clarke, MD , Jason D. Pimental , Hillary Z. Kimbrell , Klaus J. Busam MD

Conference: ASDP, Oct 2016, Chicago IL


Poster 2

Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes

Authors: Jennifer Ko, Balwir Matharoo-Ball, Steven Billings, Brian Thomson, Jean Tang, Kavita Sarin, Emily Cai, Jinah Kim, Colleen Rock, Hillary Kimbrell, Darl Flake, Bryan Warf, Jonathan Nelson, Thaylon Davis, Catherine Miller, Kristen Rushton, Anne-Renee Hartman, Richard Wenstrup, Loren Clarke

Conference: ASDP, Oct 2016, Chicago IL


Poster 3

An Independent Validation of a Gene Expression Signature to Differentiate Malignant Melanoma from Benign Melanocytic Nevi

Authors: H. Kimbrell, MD; L. E. Clarke, MD; D. D. Flake II, MS; K. Busam, MD; C. Cockerell, MD; K. Helm, MD; J. McNiff, MD; J. Reed, MD; J. Tschen, MD; J. Kim, MD; R. Barnhill, MD; R. Elenitsas, MD; V. G. Prieto, MD ; J. Nelson, BS; K. A. Kolquist, MD; K. L. Brown, PhD; M. B. Warf, PhD; B. B. Roa, PhD; R. J. Wenstrup, MD

Conference: USCAP 2016, Mar 2016, Seattle WA


Poster 4

A Retrospective Study of the Influence of a Gene Expression Signature on the Treatment of the Melanocytic Tumors by Dermatologists

Authors: Clay J. Cockerell, Jaime Tschen, Steven D. Billings, Colleen Rock, Brent Evans, Loren E. Clarke

Conference: AAD, Mar 2015, San Francisco CA


Poster 5

A Retrospective Study of the Influence of a Gene Expression Signature on the Treatment of the Melanocytic Tumors

Authors: Colleen Rock, PharmD, PhD; Clay Cockerell, MD; Jaime Tschen, MD; Steven Billings, MD; Brent Evans, MS; John Kidd, MS; Krystal Brown, PhD; Loren E. Clarke, MD

Conference: ASDP, Oct 2015, San Francisco CA


Poster 6

A Clinically Validated Gene Expression Score Impacts Diagnosis and Management Recommendations of Melanocytic Lesions by Dermatopathologists

Authors: Loren E Clarke, Emily Bess, Brent Evans, John Kidd, Kathryn A Kolquist, Colleen Rock

Conference: NCCN, March 2015


Poster 7

A Clinically Validated Gene Expression Score Impacts Diagnosis and Management Recommendations of Melanocytic Lesions by Dermatopathologists

Authors: Loren E Clarke, Emily Bess, Kathryn Kolquist, Brent Evans, Kelsey Moyes, Colleen Rock

Conference: CAP 2014, September 2014, Chicago IL- Poster Presentation


Poster 8

The Influence Of A Gene Expression Signature On The Diagnosis And Recommended Treatment Of Melanocytic Tumors By Dermatopathologists

Authors: Loren E Clarke, Emily Bess, Kelsey Moyes, Brent Evans, Kathryn A Kolquist, Colleen Rock

Conference: ASCO 2014, May 2014, Chicago, IL- Poster Presentation


Poster 9

Development And Validation Of A Gene Expression Signature To Distinguish Malignant Melanoma From Benign Nevi

Authors: Colleen Rock, Loren E Clarke, M. Bryan Warf, Darl D Flake II, Anne-Renee Hartman, Steven Tahan, Christopher R. Shea, Pedram Gerami, Jane Messina, Richard J. Wenstrup, Kristen Rushton, Kirstin M. Roundy, Benjamin Roa, Kathryn A. Kolquist, Alexander Gutin, Steven D. Billings, Sancy Ann Leachman.

Conference: ASCO 2014, May 2014, Chicago, IL- Poster Presentation


Poster 10

Development of a Gene Expression Signature to Differentiate Malignant Melanoma From Benign Melanocytic Nevi

Authors: Loren E. Clarke, Carola Berking, Steven Tahan, Christopher R. Shea, Darl D. Flake II, Alexander Gutin, Kathryn A. Kolquist, Anne-Renee Hartman, Benjamin Roa, and M. Bryan Warf.

Conference: Society for Melanoma Research International Congress, November 17-19, 2013, Philadelphia, PA- Poster Presentation


Poster 11

The Clinical Impact of a Gene Expression Signature That Differentiates Benign Nevi From Malignant Melanoma

Authors: Colleen Rock, Steven D. Billings, Klaus J. Busam, David E. Elder, Pedram Gerami, Melissa Gill, Jane L. Messina, Steven R. Tahan, Kelsey Moyes, M. Bryan Warf, Sancy A. Leachman, Loren E. Clarke

Conference: United States and Canada Academy of Pathology, March 5, 2014, San Diego, CA. Poster Presentation

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